Key features

• Simple to use, fast and accurate
• Can be used as a stand-alone instrument
• Allows testing of sensitivity to both hot and cold stimulus
• Unmatched temperature stability and control for both heat and cold
• Fast reach to set temperatures
• Homogeneous temperature surface
• Practical foot switch timing operation
• Optional Ramp software will allow the user to define temperature ramps and loops (slope in °C/min, start and end points) and store results

Domains of application

• Analgesic drug screening
• Basal pain sensitivity phenotyping
• Integrated supraspinal responses
• Pain sensitivity alterations induced by a specific experimental context change
• Pain sensitivity alterations induced by genetic manipulations
• Animal Models of Nociception (rats and mice)

! METHOD VALIDATION ! Publication

Bioseb team presents its respectful thanks to research team of Prof. Poisbeau (Institut des Neurosciences Cellulaires et Intégratives de Strasbourg), who validated the temperature ramps method used by the Cold and Hot Plate Test during in following study:

Differentiating Thermal Allodynia and Hyperalgesia Using Dynamic Hot and Cold Plate in Rodents, by I. Yalcin, A. Charlet, MJ. Freund-Mercier, M. Barrot and P. Poisbeau, in The Journal of Pain, 2009