Detail Produk
Features
Bioseb offers a powerful dual approach system based on vibrations detection and video-based motor activity analysis for automating the Porsolt Forced Swimming Test. Using the state-of-the-art video tracking algorithms combined with each beaker vibration, the software solution allows the researcher to analyse and separate different behaviours via a calibration process that learned from an expert in the lab.
Up to 4 animals (mouse or rat) can be tested simultaneously. A manual set-up would only allow the assessment of 1 animal at a time.
Using the FST DUAL SENSOR, the researcher will be able to record video of the trials, calculate the immobility time, swimming time, and struggling time for each animal tested and do so in batches of four. Each acquisition can be replayed and re-analyzed later with different settings : thus, a calibration made by an expert from another lab could be used as well. Results can be exported to any software of choice for further analysis.
The management of the Porsolt Forced Swimming Test experiment is facilitated via a list of animals that can be entered into the software or imported from excel. Several possibilities for randomization are presented, and the randomized list can be exported, imported, and printed. Runs can be paused or started at any time.
Bioseb’s Forced Swimming Test (Porsolt): New FST DUAL SENSOR – Software screen-shots
Domains of application
• Review of antidepressant activity
• Primary screening test for antidepressants
• Evaluation of psycho-stimulants
• Evaluation of anxiety treatments
Examples of Agents used are Imiprimine, Fluoxetine, Desipramine, and Venlafaxine.
Forced Swimming Test: New FST DUAL SENSOR
TYPE : BIO-FST-DSM
SPECIFICATION :
| Accuracy | After one-time initial calibration (6 min) : 4% variability |
| Data Output | xls type, presented per rat/mouse or per groups & time period (every minutes) |
| Dimensions – Animal Container | Graduated Beakers – 17 cm diameter, 20 cm height for mice Graduated Beakers – 30 cm diameter, 50 cm height for rats |
| Dimensions – Overall | 60 x 60 x 120 for the Mouse version 80 x 80 x 180 for the Rat version |
| Power Supply | PC USB port |
| Sampling Rate | 300Hz, encrypted (glp) averaged and recorded synchronously with video images |
| Software | Allows definition of 3 activity levels: Immobility, Swimming and Climbing (struggling) |
| Technology | Learning machine TYC algorithm : combines video tracking and vibrations Replay and control : At any time, remotely. Scoring tool included for calibration, may be used for training purpose and comparison with expert |
The new Forced Swimming Test system from Bioseb uses a dual approach:
Combining a double input from vibrations and video,
the TYC (Train-Your-Computer) algorithm compares both inputs to determine the animal’s behavior in real time, making results completely operator-independent.
Experiment manager, analysis module, replay possibilities and the TYC algorithm are some of the features that make FST DUAL SENSOR a very innovative and easy to use instrument for both mice or rats studies (up to 4 animals can be tested at a time), based on the famous Porsolt Test, or “behavioral despair” test